I don’t know much about DNA
Posted on July 15, 2006
But David Dean does. He has his own lab working on gene therapy research at Northwestern University in Chicago.
My interests are in understanding how things move from one place to another and across membranes in cells. I received my PhD at UC Berkeley working on sugar transport in E. coli and then did postdoctoral work at UCLA on SV40 nuclear import and viral assembly. My first faculty position was in the Department of Microbiology and Immunology at the University of South Alabama College of Medicine, where I turned my attention to understanding how plasmids enter the nulcei of non-dividing (and dividing) cells. Although almost everyone who transfects mammalian cells routinely, does so in dividing cultures, we usually do not have the luxury of targeting dividing cells. Consequently, if gene therapy is to work, we have to understand how DNA gets into the nucleus.
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